Fanconi Anemias

《英文msh詞典》Fanconi Anemias
[入口詞] Fanconi Anemias
[主題詞] Fanconi Anemia
[英文釋義] Congenital disorder affecting all bone marrow elements,resulting in anemia,leukopenia,and thrombopenia,and associated with cardiac,renal,and limb malformations as well as dermal pigmentary changes. Spontaneous chromosome breakage is a feature of this disease along with predispostion to leukemia. There are at least 7 complementation groups in Fanconi anemia: FANCA,FANCB,FANCC,FANCD,FANCE,FANCF,FANCG. (from Online Mendelian Inheritance in Man,http://www.ncbi.nlm.nih.gov/Omim,MIM# 227650,April 23,2001)